@solarboat (39147):
Habár nem nekem szólt a kérdés.
Egyetlen cikket találtam erre a hatására vonatkozólag:
Induction of Apoptosis in Human Colon Carcinoma HCT116 Cells
Using a Water Extract of Lepidium virginicum L.
Yang-Hui Chae
et al.
J Korean Soc Food Sci Nutr 40(5), 649-659(2011)
To examine the anti-cancer effects of Lepidium virginicum L., the anti-proliferative and pro-apoptotic effects
of a water extract of L. virginicum leaves (WELVL) and of L. virginicum roots (WELVR) were investigated
in HCT116 human colon carcinoma cells. The treatment of HCT116 cells with WELVL and WELVR resulted
in the inhibition of growth and morphological changes in a concentration-dependent manner by inducing
apoptosis. The growth inhibition and apoptosis induction by WELVR was stronger than that of WELVL thus,
we determined that WELVR was the more optimal extract for this study. The increased apoptotic events in
HCT116 cells caused by WELVR were associated with an up-regulation of Fas ligand, Bax, and Bad expression,
a down-regulation of Bcl-2, Bcl-XL, and Bid expression, and a decrease in the mitochondrial membrane potential
(MMP, Δψm). WELVR treatment induced the proteolytic activation of caspase-3, -8, and -9, and the degradation
of caspase-3 substrate proteins, such as poly (ADP-ribose) polymerase (PARP), β-catenin, and phospholipase
C-γ1 (PLC-γ1). In addition, apoptotic cell death induced by WELVR was correlated with a down-regulation
of inhibitors of the apoptosis protein (IAP) family, such as the X-linked inhibitor of apoptosis protein (XIAP),
cIAP-1, and cIAP-2. These findings suggest that the WELVR-induced inhibition of cell proliferation is asso-
ciated with the induction of apoptotic cell death. WELVR may be a potential chemotherapeutic agent for the
control of HCT116 human colon carcinoma cells.
(a cikk free full text vátozata letölthető)
Ahhoz képest, hogy "csodaszer" csak egy ilyen jellegű cikk foglalkozik a hatásával... Az, hogy HCT116 human colon carcinoma sejtek ellen, adott
in vitro kísérletben hatékonynak bizonyultak, még messze van attól, hogy "csodaszernek" minősítsük, IMHO.